منابع مشابه
Retrograde Signaling Causes Excitement
Retrograde signaling is a powerful tool to shape synaptic transmission, typically inducing inhibition of transmitter release. A new study published in this issue of Neuron by Carta et al. (2014) now provides strong support for arachidonic acid as a potentiating retrograde messenger.
متن کامل9-cis retinoic acid signaling: changing partners causes some excitement.
Reports on the role of retinoids in cell metabolism can be traced back almost a century, when the then-unknown vitamin A present in dietary lipids was found to be essential for normal growth {McCollum and Davis 1913; Osborne and Mendel 1913}. Since then, the profound effect of retinoic acid IRA}, a derivative of vitamin A, on development and differentiation has been documented in numerous publi...
متن کاملMitochondrial retrograde signaling.
Mitochondrial retrograde signaling is a pathway of communication from mitochondria to the nucleus under normal and pathophysiological conditions. The best understood of such pathways is retrograde signaling in the budding yeast Saccharomyces cerevisiae. It involves multiple factors that sense and transmit mitochondrial signals to effect changes in nuclear gene expression; these changes lead to ...
متن کاملCauses of retrograde flow in fish keratocytes.
Confronting motile cells with obstacles doubling as force sensors we tested the limits of the driving actin and myosin machinery. We could directly measure the force necessary to stop actin polymerization as well as the force present in the retrograde actin flow. Combined with detailed measurements of the retrograde flow velocity and specific manipulation of actin and myosin we found that actin...
متن کاملOn Trk for Retrograde Signaling
Target-derived neurotrophins like nerve growth factor (NGF) mediate biological effects by binding to and activating Trk neurotrophin receptors at nerve terminals. The activated Trk receptors then stimulate local effects at nerve terminals, and retrograde effects at neuronal cell bodies that often reside at considerable distances from the terminals. However, the nature of the retrograde signal h...
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ژورنال
عنوان ژورنال: Neuron
سال: 2014
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2014.02.003